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We acknowledge with gratitude the financial support for research provided by the Heart and Stroke Foundations of Ontario and Canada, the Canadian Institute of Health Research, the Ontario Research and Development Challenge Fund (ORDCF), The National Cancer Institute of Canada, the Hamilton Health Sciences, the Hamilton Health Foundation, McMaster University, and the Ronald K. Fraser Foundation. We also acknowledge the extensive support we have received from several pharmaceutical companies. We are particularly grateful to the Ontario Research and Development Challenge Fund for their support to encourage the commercialization of our research.